Protein NDRG4

Definition:

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

References:

[1]. Shinichi Nishimoto, et al. A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. Eur J Biochem. 2003 Jun;270(11):2521-31. [Content Brief]

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