Protein phosphatase 1 regulatory subunit 15B

Definition:

Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.

References:

[1]. Kristin D Kernohan, et al. Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability. Hum Mol Genet. 2015 Nov 15;24(22):6293-300. [Content Brief]

[2]. Baroj Abdulkarim, et al. A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Diabetes. 2015 Nov;64(11):3951-62. [Content Brief]

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