Protein RD3

Definition:

Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina (By similarity).

References:

[1]. Hanna Wimberg, et al. Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3. Front Mol Neurosci. 2018 Feb 21;11:52. [Content Brief]

[2]. Igor V Peshenko, et al. Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein. J Biol Chem. 2016 Sep 9;291(37):19713-23. [Content Brief]

[3]. Igor V Peshenko, et al. Retinal degeneration 3 (RD3) protein, a retinal guanylyl cyclase regulator, forms a monomeric and elongated four-helix bundle. J Biol Chem. 2019 Feb 15;294(7):2318-2328. [Content Brief]

[4]. Igor V Peshenko, et al. Retinal degeneration 3 (RD3) protein inhibits catalytic activity of retinal membrane guanylyl cyclase (RetGC) and its stimulation by activating proteins. Biochemistry. 2011 Nov 8;50(44):9511-9. [Content Brief]

[5]. Seifollah Azadi, et al. RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21158-63. [Content Brief]

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