Protein SSXT

Definition:

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.

References:

[1]. Toshiharu Iwasaki, et al. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology. 2005 Sep;146(9):3892-9. [Content Brief]

[2]. Aktan Alpsoy, et al. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem. 2018 Mar 16;293(11):3892-3903. [Content Brief]

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