Protein Wnt-3a

Definition:

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro).

References:

[1]. Bryan T MacDonald, et al. Disulfide bond requirements for active Wnt ligands. J Biol Chem. 2014 Jun 27;289(26):18122-36. [Content Brief]

[2]. Emiko Mihara, et al. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. Elife. 2016 Feb 23;5:e11621. [Content Brief]

[3]. Eric Bourhis, et al. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem. 2010 Mar 19;285(12):9172-9. [Content Brief]

[4]. Lenka Doubravska, et al. Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Cell Signal. 2011 May;23(5):837-48. [Content Brief]

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