Pseudomonas aeruginosa infection

Definition:

Pseudomonas aeruginosa is a leading cause of nosocomial bloodstream infections, ranking third among gram-negative bacteria, after Escherichia coli and Klebsiella species. Intrinsic resistance has been traditionally attributed to the low permeability of cellular envelopes together with the presence of chromosomally-encoded detoxification systems such as multidrug efflux pumps or antibiotic inactivating enzymes. Some strains acquire increased resistance via the horizontal transfer of resistance determinants and mutations in chromosomal genes.

References:

[1]. B Henrichfreise, et al. Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation. Antimicrob Agents Chemother. 2007 Nov;51(11):4062-70. [Content Brief]

[2]. Carolina Alvarez-Ortega, et al. The intrinsic resistome of Pseudomonas aeruginosa to β-lactams. Virulence. 2011 Mar-Apr;2(2):144-6. [Content Brief]

[3]. E B El Amari, et al. Influence of previous exposure to antibiotic therapy on the susceptibility pattern of Pseudomonas aeruginosa bacteremic isolates. Clin Infect Dis. 2001 Dec 1;33(11):1859-64. [Content Brief]

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