Puromycin-sensitive aminopeptidase

Definition:

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.

References:

[1]. L Stoltze, et al. Two new proteases in the MHC class I processing pathway. Nat Immunol. 2000 Nov;1(5):413-8. [Content Brief]

[2]. Soma Sengupta, et al. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006 Dec 19;45(50):15111-9. [Content Brief]

[3]. Y Yamamoto, et al. Puromycin-sensitive alanyl aminopeptidase from human liver cytosol: purification and characterization. Forensic Sci Int. 2000 Sep 11;113(1-3):143-6. [Content Brief]

[4]. Eunkyung Kim, et al. Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner. J Immunol. 2009 Dec 1;183(11):7379-87. [Content Brief]

[5]. N Bhutani, et al. Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation. EMBO J. 2007 Mar 7;26(5):1385-96. [Content Brief]

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