2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. SHP2 Phosphatase
  4. Bis(maltolato)oxovanadium(IV)

Bis(maltolato)oxovanadium(IV)  (Synonyms: BMOV)

Cat. No.: HY-118567 Purity: 99.34%
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Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer.

For research use only. We do not sell to patients.

Bis(maltolato)oxovanadium(IV) Chemical Structure

Bis(maltolato)oxovanadium(IV) Chemical Structure

CAS No. : 38213-69-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
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10 mM * 1 mL in DMSO USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

Bis(maltolato)oxovanadium(IV) Related Antibodies

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Description

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer[1][2].

IC50 & Target

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)[2]
In Vitro

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis(maltolato)oxovanadium(IV) Related Antibodies
In Vivo

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)[1]
Dosage: 0.75-3.0 mmol
Administration: Intraperitoneal injection; twice weekly; for 6 weeks
Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
Molecular Weight

317.15

Formula

C12H10O7V
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=[V+2]([O-]C1=C2C)([O]=C1C=CO2)([O]=C3C=CO4)[O-]C3=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (78.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1531 mL 15.7654 mL 31.5308 mL
5 mM 0.6306 mL 3.1531 mL 6.3062 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.34%

COA (256 KB) HNMR (253 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1531 mL 15.7654 mL 31.5308 mL 78.8271 mL
5 mM 0.6306 mL 3.1531 mL 6.3062 mL 15.7654 mL
10 mM 0.3153 mL 1.5765 mL 3.1531 mL 7.8827 mL
15 mM 0.2102 mL 1.0510 mL 2.1021 mL 5.2551 mL
20 mM 0.1577 mL 0.7883 mL 1.5765 mL 3.9414 mL
25 mM 0.1261 mL 0.6306 mL 1.2612 mL 3.1531 mL
30 mM 0.1051 mL 0.5255 mL 1.0510 mL 2.6276 mL
40 mM 0.0788 mL 0.3941 mL 0.7883 mL 1.9707 mL
50 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5765 mL
60 mM 0.0526 mL 0.2628 mL 0.5255 mL 1.3138 mL
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Bis(maltolato)oxovanadium(IV) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis(maltolato)oxovanadium(IV)38213-69-3BMOVSHP2PhosphataseSrc homology phosphatase 2PTPN11PTPSHP-1type-2diabetesinsulinmetabolicphenotypeglucoseuptakePTP1BHCPTPAHPTPβInhibitorinhibitorinhibit

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