2. Neuronal Signaling GPCR/G Protein
  3. Sigma Receptor mAChR
  4. Blarcamesine

Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.

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Blarcamesine Chemical Structure

Blarcamesine Chemical Structure

CAS No. : 195615-83-9

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Based on 2 publication(s) in Google Scholar

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Blarcamesine Related Antibodies

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Description

Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome[1].

IC50 & Target

Sigma 1 Receptor

 

In Vivo

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Mecp2tm1.1Bird/J HET (C57 background) mice[1]
Dosage: 10 mg/kg, 30 mg/kg
Administration: Oral administration, daily, for 6.5 weeks
Result: Reverse the deficits observed in the HET animals.
Clinical Trial
Molecular Weight

281.39

Formula

C19H23NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (444.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5538 mL 17.7689 mL 35.5379 mL
5 mM 0.7108 mL 3.5538 mL 7.1076 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5538 mL 17.7689 mL 35.5379 mL 88.8447 mL
5 mM 0.7108 mL 3.5538 mL 7.1076 mL 17.7689 mL
10 mM 0.3554 mL 1.7769 mL 3.5538 mL 8.8845 mL
15 mM 0.2369 mL 1.1846 mL 2.3692 mL 5.9230 mL
20 mM 0.1777 mL 0.8884 mL 1.7769 mL 4.4422 mL
25 mM 0.1422 mL 0.7108 mL 1.4215 mL 3.5538 mL
30 mM 0.1185 mL 0.5923 mL 1.1846 mL 2.9615 mL
40 mM 0.0888 mL 0.4442 mL 0.8884 mL 2.2211 mL
50 mM 0.0711 mL 0.3554 mL 0.7108 mL 1.7769 mL
60 mM 0.0592 mL 0.2961 mL 0.5923 mL 1.4807 mL
80 mM 0.0444 mL 0.2221 mL 0.4442 mL 1.1106 mL
100 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.8884 mL
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Blarcamesine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blarcamesine195615-83-9Sigma ReceptormAChRMuscarinic acetylcholine receptorAlzheimer'sdiseaseRettsyndromeanticonvulsantanti-amnesicneuroprotectiveantidepressantInhibitorinhibitorinhibit

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