CaV1.3 antagonist-1

Name: CaV1.3 antagonist-1
Brand: MedChemExpress
SKU: HY-134542
Rating: 4.5 (1 reviews)

Cat. No.: HY-134542 Purity: 98.12%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CaV1.3 antagonist-1 is a potent and highly selective Ca_V1.3 L-type calcium channel (LTCC) antagonist with an IC₅₀ of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca_V1.3 LTCC >600-fold more potently than Ca_V1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.

For research use only. We do not sell to patients.

CaV1.3 antagonist-1 Chemical Structure

CAS No. : 1391385-57-1

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1540	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2470	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Ca_V1.3

1.7 μM (IC₅₀)

In Vitro

CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for Ca_V1.3 and Ca_V1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.80

Formula

C₁₇H₁₉ClN₂O₃

CAS No.

1391385-57-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C1N(C2CCCC2)C(CC(N1CCC3=CC=CC(Cl)=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (298.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9869 mL	14.9343 mL	29.8686 mL
5 mM	0.5974 mL	2.9869 mL	5.9737 mL
10 mM	0.2987 mL	1.4934 mL	2.9869 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.12%

Select Batch:

Data Sheet (271 KB) SDS (0 KB)

COA (247 KB) HNMR (242 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Soosung Kang, et al. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat Commun. 2012;3:1146. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9869 mL	14.9343 mL	29.8686 mL	74.6714 mL
	5 mM	0.5974 mL	2.9869 mL	5.9737 mL	14.9343 mL
	10 mM	0.2987 mL	1.4934 mL	2.9869 mL	7.4671 mL
	15 mM	0.1991 mL	0.9956 mL	1.9912 mL	4.9781 mL
	20 mM	0.1493 mL	0.7467 mL	1.4934 mL	3.7336 mL
	25 mM	0.1195 mL	0.5974 mL	1.1947 mL	2.9869 mL
	30 mM	0.0996 mL	0.4978 mL	0.9956 mL	2.4890 mL
	40 mM	0.0747 mL	0.3734 mL	0.7467 mL	1.8668 mL
	50 mM	0.0597 mL	0.2987 mL	0.5974 mL	1.4934 mL
	60 mM	0.0498 mL	0.2489 mL	0.4978 mL	1.2445 mL
	80 mM	0.0373 mL	0.1867 mL	0.3734 mL	0.9334 mL
	100 mM	0.0299 mL	0.1493 mL	0.2987 mL	0.7467 mL