2. Immunology/Inflammation
  3. COX
  4. Cimicoxib

Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar.

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Cimicoxib Chemical Structure

Cimicoxib Chemical Structure

CAS No. : 265114-23-6

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Based on 1 publication(s) in Google Scholar

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Description

Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar[1].

IC50 & Target

COX-2

 

Clinical Trial
Molecular Weight

381.81

Formula

C16H13ClFN3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(N2C(C3=CC=C(OC)C(F)=C3)=C(Cl)N=C2)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (327.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6191 mL 13.0955 mL 26.1910 mL
5 mM 0.5238 mL 2.6191 mL 5.2382 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6191 mL 13.0955 mL 26.1910 mL 65.4776 mL
5 mM 0.5238 mL 2.6191 mL 5.2382 mL 13.0955 mL
10 mM 0.2619 mL 1.3096 mL 2.6191 mL 6.5478 mL
15 mM 0.1746 mL 0.8730 mL 1.7461 mL 4.3652 mL
20 mM 0.1310 mL 0.6548 mL 1.3096 mL 3.2739 mL
25 mM 0.1048 mL 0.5238 mL 1.0476 mL 2.6191 mL
30 mM 0.0873 mL 0.4365 mL 0.8730 mL 2.1826 mL
40 mM 0.0655 mL 0.3274 mL 0.6548 mL 1.6369 mL
50 mM 0.0524 mL 0.2619 mL 0.5238 mL 1.3096 mL
60 mM 0.0437 mL 0.2183 mL 0.4365 mL 1.0913 mL
80 mM 0.0327 mL 0.1637 mL 0.3274 mL 0.8185 mL
100 mM 0.0262 mL 0.1310 mL 0.2619 mL 0.6548 mL
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Cimicoxib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cimicoxib265114-23-6UR-8880UR8880UR 8880COXCyclooxygenaseAnti-inflammatory activityOrally activeAnalgesic activitySelectiveInhibitorinhibitorinhibit

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