2. Peptides
  3. [D-p-Cl-Phe6,Leu17]-VIP TFA

[D-p-Cl-Phe6,Leu17]-VIP TFA is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP TFA has no activity on glucagon, secretin or GRF receptors.

For research use only. We do not sell to patients.

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[D-p-Cl-Phe6,Leu17]-VIP TFA Chemical Structure

[D-p-Cl-Phe6,Leu17]-VIP TFA Chemical Structure

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1 mg USD 72 In-stock
5 mg USD 180 In-stock
10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of [D-p-Cl-Phe6,Leu17]-VIP TFA:

[D-p-Cl-Phe6,Leu17]-VIP TFA Related Antibodies

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Description

[D-p-Cl-Phe6,Leu17]-VIP TFA is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP TFA has no activity on glucagon, secretin or GRF receptors[1][2][3].

IC50 & Target

IC50: 125.8 nM (VIP receptor)[1]
Molecular Weight

3456.22

Formula

C150H240F3ClN44O44
Appearance

Solid

Color

White to off-white

Sequence

His-Ser-Asp-Ala-Val-{Cl-Phe}-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Sequence Shortening

HSDAV-{Cl-Phe}-TDNYTRLRKQLAVKKYLNSILN-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (28.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2893 mL 1.4467 mL 2.8933 mL
5 mM 0.0579 mL 0.2893 mL 0.5787 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2893 mL 1.4467 mL 2.8933 mL 7.2333 mL
5 mM 0.0579 mL 0.2893 mL 0.5787 mL 1.4467 mL
10 mM 0.0289 mL 0.1447 mL 0.2893 mL 0.7233 mL
15 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.4822 mL
20 mM 0.0145 mL 0.0723 mL 0.1447 mL 0.3617 mL
25 mM 0.0116 mL 0.0579 mL 0.1157 mL 0.2893 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-p-Cl-Phe6,Leu17]-VIPOthersVasoactiveintestinalpeptideVIPglucagon-secretinneuroimmunomodulationInhibitorinhibitorinhibit

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