D-Pro-Phe-Arg-Chloromethylketone

Cat. No.: HY-P4245 Purity: 98.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

D-Pro-Phe-Arg-Chloromethylketone Chemical Structure

CAS No. : 88546-74-1

Size	Price	Stock	Quantity
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation^[1].

Molecular Weight

450.96

Formula

C₂₁H₃₁ClN₆O₃

CAS No.

88546-74-1

Appearance

Solid

Color

White to off-white

Sequence

{d-Pro}-Phe-{Arg-Chloromethylketone}

Sequence Shortening

{d-Pro}-F-{Arg-Chloromethylketone}

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (221.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2175 mL	11.0875 mL	22.1749 mL
5 mM	0.4435 mL	2.2175 mL	4.4350 mL
10 mM	0.2217 mL	1.1087 mL	2.2175 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.95%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (201 KB) MS (219 KB)

Handling Instructions (2659 KB)

References

[1]. Katrin F Nickel, et al. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2175 mL	11.0875 mL	22.1749 mL	55.4373 mL
	5 mM	0.4435 mL	2.2175 mL	4.4350 mL	11.0875 mL
	10 mM	0.2217 mL	1.1087 mL	2.2175 mL	5.5437 mL
	15 mM	0.1478 mL	0.7392 mL	1.4783 mL	3.6958 mL
	20 mM	0.1109 mL	0.5544 mL	1.1087 mL	2.7719 mL
	25 mM	0.0887 mL	0.4435 mL	0.8870 mL	2.2175 mL
	30 mM	0.0739 mL	0.3696 mL	0.7392 mL	1.8479 mL
	40 mM	0.0554 mL	0.2772 mL	0.5544 mL	1.3859 mL
	50 mM	0.0443 mL	0.2217 mL	0.4435 mL	1.1087 mL
	60 mM	0.0370 mL	0.1848 mL	0.3696 mL	0.9240 mL
	80 mM	0.0277 mL	0.1386 mL	0.2772 mL	0.6930 mL
	100 mM	0.0222 mL	0.1109 mL	0.2217 mL	0.5544 mL