Decanoyl-RVKR-CMK (Synonyms: DecRVKRcmk)

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Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication.

For research use only. We do not sell to patients.

Decanoyl-RVKR-CMK Chemical Structure

CAS No. : 150113-99-8

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Decanoyl-RVKR-CMK TFA In-stock

1 Publications Citing Use of MCE Decanoyl-RVKR-CMK

•PLoS Pathog. 2023 Nov 10;19(11):e1011789. [Abstract]

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Biological Activity
Purity & Documentation
References
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Description

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication^[1].

In Vitro

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2_ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell^[1].
Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.
Concentration:	35 and 70 µΜ.
Incubation Time:	7 days.
Result:	Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).

Molecular Weight

744.41

Formula

C₃₄H₆₆ClN₁₁O₅

CAS No.

150113-99-8

SMILES

CCCCCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(CCl)=O)CCCNC(N)=N)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [Content Brief]

[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608. [Content Brief]

Decanoyl-RVKR-CMK Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decanoyl-RVKR-CMK150113-99-8DecRVKRcmkHIVHuman immunodeficiency virusglycoproteinVGF glycoproteinVGFHIV-2 ROD infectionreplicationInhibitorinhibitorinhibit

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