2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. DL-Mevalonolactone

DL-Mevalonolactone  (Synonyms: (±)-Mevalonolactone; Mevalolactone)

Cat. No.: HY-107855 Purity: ≥98.0%
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DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling[2][4].

For research use only. We do not sell to patients.

DL-Mevalonolactone Chemical Structure

DL-Mevalonolactone Chemical Structure

CAS No. : 674-26-0

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DL-Mevalonolactone:

DL-Mevalonolactone Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DL-Mevalonolactone

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy[3]. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling[2][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

DL-Mevalonolactone (0.1-1 mM, 0-72 h) induces inflammatory response with upregulated IL1B expression,induces oxidative stress with mitochondrial membrane depolarization and increased levels of SOD2, HemeOX and ROS[4]. DL-Mevalonolactone(1-2 mM) promotes peroxidation, inhibits activity of aconitase in brain[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Mevalonolactone Related Antibodies

Real Time qPCR[4]

Cell Line: U87-MG
Concentration: 0.1-1 mM
Incubation Time: 72 h
Result: Increased SOD, HemeOX and IL1B expression
In Vivo

DL-Mevalonolactone exhibits efficacy against statin induced myopathy in C57BL/6 mice (200 mg/kg, p.o. for 14 days), without toxicity (2 g/kg, p.o. for 7 days)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with cerivastatin/simvastatin induced myopathy [3]
Dosage: 200 mg/kg
Administration: oral gavage
Result: Increased muschle strength and endurance in hanging wire and grip tests.
Molecular Weight

130.14

Formula

C6H10O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1CC(C)(O)CCO1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (768.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (384.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6840 mL 38.4202 mL 76.8403 mL
5 mM 1.5368 mL 7.6840 mL 15.3681 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (15.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (15.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (845.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.6840 mL 38.4202 mL 76.8403 mL 192.1008 mL
5 mM 1.5368 mL 7.6840 mL 15.3681 mL 38.4202 mL
10 mM 0.7684 mL 3.8420 mL 7.6840 mL 19.2101 mL
15 mM 0.5123 mL 2.5613 mL 5.1227 mL 12.8067 mL
20 mM 0.3842 mL 1.9210 mL 3.8420 mL 9.6050 mL
25 mM 0.3074 mL 1.5368 mL 3.0736 mL 7.6840 mL
30 mM 0.2561 mL 1.2807 mL 2.5613 mL 6.4034 mL
40 mM 0.1921 mL 0.9605 mL 1.9210 mL 4.8025 mL
50 mM 0.1537 mL 0.7684 mL 1.5368 mL 3.8420 mL
60 mM 0.1281 mL 0.6403 mL 1.2807 mL 3.2017 mL
80 mM 0.0961 mL 0.4803 mL 0.9605 mL 2.4013 mL
100 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.9210 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DL-Mevalonolactone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Mevalonolactone674-26-0(±)-Mevalonolactone MevalolactoneEndogenous MetaboliteInflammationC57BL/6 miceHMGCR mutationstatin myopathyInhibitorinhibitorinhibit

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