1. PROTAC Autophagy
  2. Ligands for E3 Ligase Autophagy
  3. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc 

Cat. No.: HY-163221
Handling Instructions

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

For research use only. We do not sell to patients.

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc Chemical Structure

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc Chemical Structure

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Description

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]

Molecular Weight

567.68

Formula

C30H41N5O6

SMILES

O=C1NC(CC[C@@H]1N2C(C3=C(C=CC(N4CCN(CC4)C[C@H]5CC[C@@H](CC5)N(C)C(OC(C)(C)C)=O)=C3)C2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc
Cat. No.:
HY-163221
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