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Etrolizumab  (Synonyms: rhuMAb Beta7; RG7413; PRO145223)

Cat. No.: HY-P9984 Purity: 99.56%
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Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD).

For research use only. We do not sell to patients.

Etrolizumab Chemical Structure

Etrolizumab Chemical Structure

CAS No. : 1044758-60-2

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Description

Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD)[1][2].

IC50 & Target[1]

α4β7

 

αEβ7

 

In Vitro

Etrolizumab (rhuMAb Beta7) binds the β7 subunit of both α4β7 and αEβ7 integrins with high affinity, with Kd values of 18 nM, 1800 pM, 181 pM, 116 pM, 57 pM, 31.7 pM, and 25.7 pM for Human α4β7, Human αEβ7-293, Mouse α4β7-38C13, Human α4β7-293, Rabbit PBLs, Human PBLs, and Cyno PBLs, respectively[1].
Etrolizumab (RPMI 8866 cells and αEβ7-293 cells) blocks the interaction of α4β7 with its cognate ligands MAdCAM-1 and VCAM-1 with IC50 values of 0.075 and 0.089 nM, respectively, and blocks the interaction between αEβ7 and its ligand E-cadherin with an IC50 value of 3.96 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etrolizumab Related Antibodies
In Vivo

Etrolizumab (rhuMAb Beta7; 5 mg/kg; i.v.; once; normal female BALB/c mice) decreases β7 integrins on T lymphocytes[2].
Etrolizumab (200 µg (100 µL); i.p.; once) inhibits lymphocyte homing in the CD45RBhigh T cell-reconstituted SCID mouse model of colitis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal female BALB/c mice (17-21 g)[2]
Dosage: 5 mg/kg
Administration: Intravenous injection; once
Result: Had 98.3% of intraepithelial CD8+ T-cell β7 integrin receptors and 90.0% of intraepithelial CD4+ T-cell β7 integrin receptors after 24 h.
Animal Model: SCID mouse model of colitis[2]
Dosage: 200 µg (100 µL)
Administration: Intraperitoneal injection; once
Result: Blocked lymphocyte recruitment and homing to the inflamed colon.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Etrolizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.56%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Etrolizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etrolizumab1044758-60-2rhuMAb Beta7 RG7413 PRO145223rhuMAb Beta 7rhuMAb Beta-7RG7413RG 7413RG-7413PRO145223PRO 145223PRO-145223Integrininflammatory bowel diseaseRPMI 8866 cellsgut-selectiveanti-β7 integrin monoclonal antibodyInhibitorinhibitorinhibit

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