2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Cytotoxin Topoisomerase
  4. Exatecan Intermediate 2 hydrochloride

Exatecan Intermediate 2 hydrochloride 

Cat. No.: HY-W021377A Purity: 99.33%
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Exatecan Intermediate 2 hydrochloride (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers.

For research use only. We do not sell to patients.

Exatecan Intermediate 2 hydrochloride Chemical Structure

Exatecan Intermediate 2 hydrochloride Chemical Structure

CAS No. : 2437603-23-9

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Exatecan Intermediate 2 hydrochloride Related Antibodies

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Description

Exatecan Intermediate 2 hydrochloride (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2].

IC50 & Target

Camptothecins

 

Molecular Weight

286.73

Formula

C13H16ClFN2O2
CAS No.
Appearance

Solid

Color

Gray to dark gray

SMILES

CC(NC(CCC1=C2C(N)=CC(F)=C1C)C2=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (43.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4876 mL 17.4380 mL 34.8760 mL
5 mM 0.6975 mL 3.4876 mL 6.9752 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4876 mL 17.4380 mL 34.8760 mL 87.1900 mL
5 mM 0.6975 mL 3.4876 mL 6.9752 mL 17.4380 mL
10 mM 0.3488 mL 1.7438 mL 3.4876 mL 8.7190 mL
15 mM 0.2325 mL 1.1625 mL 2.3251 mL 5.8127 mL
20 mM 0.1744 mL 0.8719 mL 1.7438 mL 4.3595 mL
25 mM 0.1395 mL 0.6975 mL 1.3950 mL 3.4876 mL
30 mM 0.1163 mL 0.5813 mL 1.1625 mL 2.9063 mL
40 mM 0.0872 mL 0.4360 mL 0.8719 mL 2.1798 mL
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Exatecan Intermediate 2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Exatecan Intermediate 22437603-23-9Exatecan Intermediate2Exatecan Intermediate-2ADC CytotoxinTopoisomeraseADC PayloadInhibitorinhibitorinhibit

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