2. Metabolic Enzyme/Protease
  3. Proteasome
  4. FiVe1

FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor. FiVe1 promotes VIM disorganization and phosphorylation during metaphase, leading to mitotic catastrophe, multinucleation, and the loss of stemness.?FiVe1 selectively and irreversibly inhibits the growth of multiple FOXC2-expressing breast cancer cell lines (HMLER cells (IC50:?267 nM); FOXC2-HMLER cells (IC50:?447 nM). FiVe1 inhibits the migration of mesenchymally transformed cells.

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FiVe1 Chemical Structure

FiVe1 Chemical Structure

CAS No. : 932359-76-7

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FiVe1 Related Antibodies

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Description

FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor[1]. FiVe1 promotes VIM disorganization and phosphorylation during metaphase, leading to mitotic catastrophe, multinucleation, and the loss of stemness.?FiVe1 selectively and irreversibly inhibits the growth of multiple FOXC2-expressing breast cancer cell lines (HMLER cells (IC50:?267 nM); FOXC2-HMLER cells (IC50:?447 nM). FiVe1 inhibits the migration of mesenchymally transformed cells[1].

IC50 & Target

IC50: VIM[1]
Molecular Weight

359.25

Formula

C18H16Cl2N4
CAS No.
SMILES

ClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1
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Purity & Documentation
References
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FiVe1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FiVe1932359-76-7FiVe 1FiVe-1ProteasomevimentinEMTcancer stem cellmitosisdrug discoveryInhibitorinhibitorinhibit

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