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  4. FM-red

FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx).

For research use only. We do not sell to patients.

FM-red Chemical Structure

FM-red Chemical Structure

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5 mg USD 690 In-stock
10 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

FM-red Related Antibodies

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Description

FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx)[1].

In Vitro

FM-red (10 μM; 30 min) is suitable for imaging protein thiols in HeLa cells[1].
FM-red (20 μM; 48 h) has no significant cytotoxicity in HeLa cells[1].
FM-red possesses a long emission wavelength (~655 nm) and fast response (~10 min) by binding to protein thiols[1].
FM-red exhibits time- and concentration-dependent fluorescence response to bovine serum albumin (BSA)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FM-red Related Antibodies
In Vivo

FM-red (10 μM; 30 min) could be used to image protein thiols in zebrafishes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

788.29

Formula

C41H46ClN5O9
Appearance

Solid

Color

Brown to black

SMILES

CN(C1=CC=C(C2=[O+]C3=C(C=CC(N(CC)CC)=C3)C(C4=C(C=CC=C4)C(N5CCC(CC5)NC(CCCN6C(C=CC6=O)=O)=O)=O)=C2)C=C1)C.O=Cl(=O)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (63.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2686 mL 6.3428 mL 12.6857 mL
5 mM 0.2537 mL 1.2686 mL 2.5371 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2686 mL 6.3428 mL 12.6857 mL 31.7142 mL
5 mM 0.2537 mL 1.2686 mL 2.5371 mL 6.3428 mL
10 mM 0.1269 mL 0.6343 mL 1.2686 mL 3.1714 mL
15 mM 0.0846 mL 0.4229 mL 0.8457 mL 2.1143 mL
20 mM 0.0634 mL 0.3171 mL 0.6343 mL 1.5857 mL
25 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2686 mL
30 mM 0.0423 mL 0.2114 mL 0.4229 mL 1.0571 mL
40 mM 0.0317 mL 0.1586 mL 0.3171 mL 0.7929 mL
50 mM 0.0254 mL 0.1269 mL 0.2537 mL 0.6343 mL
60 mM 0.0211 mL 0.1057 mL 0.2114 mL 0.5286 mL
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FM-red Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FM-redPSH-redFluorescent Dyered-emittingenvironmentsensitiveproteinthiolssulfhydrylredoxstatesthioredoxinTrxInhibitorinhibitorinhibit

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