2. Ganoderic acid B

Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM).

For research use only. We do not sell to patients.

Ganoderic acid B Chemical Structure

Ganoderic acid B Chemical Structure

CAS No. : 81907-61-1

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5 mg USD 290 In-stock
10 mg USD 420 In-stock
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Ganoderic acid B Related Antibodies

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Description

Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM)[1][2][3].

IC50 & Target

HIV-1 protease[3]
In Vitro

Ganoderic acid B (0-40 μM, 1 h) reduces TNF-α, IL-6 and IL-1β levels in cellular supernatant in LPS-induced A549 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderic acid B Related Antibodies
In Vivo

Ganoderic acid B (3 or 6 mg/kg, i.p.) protects mice from LPS-induced pneumonia[4].
Ganoderic acid B (5 mg/kg, s.c.) shows antinociceptive effects in acetic acid-induced writhing in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced pneumonia mice[4]
Dosage: 3 or 6 mg/kg
Administration: i.p.
Result: Reduced Lung dry/wet weight (W/D) and myeloperoxidase activity in lung.
Increased SOD, decreased MDA, TNF-α, IL-1β and IL-6 level.
Molecular Weight

516.67

Formula

C30H44O7
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

C[C@]([C@@]([C@]([C@H](C)CC(C[C@@H](C)C(O)=O)=O)([H])C1)(CC2=O)C)(C1=O)C([C@H](C[C@@]3([H])C4(C)C)O)=C2[C@]3(CC[C@@H]4O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (96.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9355 mL 9.6774 mL 19.3547 mL
5 mM 0.3871 mL 1.9355 mL 3.8709 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9355 mL 9.6774 mL 19.3547 mL 48.3868 mL
5 mM 0.3871 mL 1.9355 mL 3.8709 mL 9.6774 mL
10 mM 0.1935 mL 0.9677 mL 1.9355 mL 4.8387 mL
15 mM 0.1290 mL 0.6452 mL 1.2903 mL 3.2258 mL
20 mM 0.0968 mL 0.4839 mL 0.9677 mL 2.4193 mL
25 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9355 mL
30 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6129 mL
40 mM 0.0484 mL 0.2419 mL 0.4839 mL 1.2097 mL
50 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.9677 mL
60 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8064 mL
80 mM 0.0242 mL 0.1210 mL 0.2419 mL 0.6048 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganoderic acid B81907-61-1Inhibitorinhibitorinhibit

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