PARP2 - poly(ADP-ribose) polymerase 2 Gene

Homo sapiens

Also known as ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2

Gene ID: 10038 | Gene type: protein coding

About PARP2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,343,635-20,357,904 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

PARP2 Products(5)

mRNA	Protein	Name
NM_005484.4	NP_005475.2	poly [ADP-ribose] polymerase 2 isoform 1
XM_005267247.4	XP_005267304.1	poly [ADP-ribose] polymerase 2 isoform X1
XM_047430869.1	XP_047286825.1	poly [ADP-ribose] polymerase 2 isoform X3
XM_017020912.2	XP_016876401.1	poly [ADP-ribose] polymerase 2 isoform X2
NM_001042618.2	NP_001036083.1	poly [ADP-ribose] polymerase 2 isoform 2

PARP2 Protein Structure

WGR

PARP_reg

PARP

0
100
200
300
400
500
583 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+	poly(ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase diphtheria toxin-like 2	ADPRT-2
DNA ADP-ribosyltransferase PARP2	NAD(+) ADP-ribosyltransferase 2
hPARP-2	poly (ADP-ribose) polymerase family, member 2
poly (ADP-ribosyl) transferase-like 2	poly[ADP-ribose] synthase 2
poly[ADP-ribose] synthetase 2	protein poly-ADP-ribosyltransferase PARP2

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Fallopian Tube Carcinoma

Fallopian Tube Cancer	Cancer Of The Fallopian Tube
Carcinoma Of Fallopian Tube	Neoplasm Of Fallopian Tube
Fallopian Tube Neoplasms	Fallopian Tube Ca
Fallopian Tube Neoplasm	Malignant Neoplasm Of Uterine Tube
Malignant Tumor Of Fallopian Tube	Malignant Tumour Of Fallopian Tube
Tumor Of The Fallopian Tube	Tumor, Fallopian Tube, Malignant
Malignant Tumor Of Fallopian Tubes	Cancer Of Fallopian Tubes
Malignant Tubal Tumor	Tubal Cancer
Malignant Neoplasm Of Fallopian Tube	Primary Malignant Neoplasm Of Fallopian Tube
Cancer Of The Oviduct

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures

Fallopian Tube Disease

Fallopian Tube Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10162	Olaparib	Inhibitor	99.98%	Yes
HY-16106	Talazoparib	Inhibitor	99.89%	Unkown
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.80%	Yes
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-10619A	Niraparib hydrochloride	Inhibitor	99.76%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	Yes
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10129	Veliparib	Inhibitor	99.92%	Phase 3
HY-10130	Veliparib dihydrochloride	Inhibitor	99.96%	Phase 3
HY-132167	Saruparib	Inhibitor	99.79%	Phase 2
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2
HY-105303	CEP-9722	Inhibitor	/	Phase 2
HY-13536	AZD-2461	Inhibitor	99.88%	Phase 1
HY-115552	Simmiparib	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-13688A	PJ34	Inhibitor	98.11%	Unkown
HY-13688	PJ34 hydrochloride	Inhibitor	99.91%	Unkown
HY-13990	NVP-TNKS656	Inhibitor	99.66%	Unkown
HY-150207	RBN-3143	Inhibitor	99.24%	Unkown
HY-137457	Venadaparib	Inhibitor	98.11%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-100225	ME0328	Inhibitor	99.59%	Unkown
HY-14478	UPF 1069	Inhibitor	99.10%	Unkown
HY-18954	NMS-P118	Inhibitor	99.78%	Unkown
HY-19351	MN-64	Inhibitor	99.73%	Unkown
HY-122661	Mefuparib hydrochloride	Inhibitor	98.94%	Unkown
HY-108632	BYK204165	Inhibitor	98.66%	Unkown
HY-10614	A-966492	Inhibitor	99.95%	Unkown
HY-132297A	PARP1-IN-5 dihydrochloride	Inhibitor	97.21%	Unkown
HY-148566	OUL232	Inhibitor	99.82%	Unkown
HY-156419	PARP7-IN-16	Inhibitor	/	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-121719	TIQ-A	Inhibitor	99.65%	Unkown
HY-133124	PARP/PI3K-IN-1	Inhibitor	99.43%	Unkown
HY-102035	PARP-2-IN-1	Inhibitor	99.56%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.89%	Unkown
HY-105692	DR2313	Inhibitor	98.70%	Unkown
HY-132297	PARP1-IN-5	Inhibitor	/	Unkown
HY-137457A	Venadaparib hydrochloride	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-151625	PARP-2-IN-3	Inhibitor	/	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown
HY-145749	PARPYnD	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1	Inhibitor	/	Unkown
HY-105253	PARP-2/1-IN-2	Inhibitor	/	Unkown
HY-155993	YCH1899	Inhibitor	/	Unkown
HY-149800	PARP-1-IN-3	Inhibitor	99.30%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PARP2	VGNC	VGNC:53577
Felis catus	PARP2	VGNC	VGNC:80893
Rattus norvegicus	PARP2	RGD	RGD:1310568
Macaca mulatta	PARP2	VGNC	VGNC:84417
Canis familiaris	PARP2	VGNC	VGNC:54219
Mus musculus	PARP2	MGD	MGI:1341112
Others	PARP2	NCBI

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