DNAL4 - dynein axonemal light chain 4 Gene

Homo sapiens

Also known as MRMV3; PIG27

Gene ID: 10126 | Gene type: protein coding

About DNAL4

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,778,508-38,794,143 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 25.2), thyroid (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes an axonemal dynein LIGHT chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]

DNAL4 Products(1)

mRNA	Protein	Name
NM_005740.3	NP_005731.1	dynein axonemal light chain 4

DNAL4 Protein Structure

Dynein_light

0
105 a.a.

Protein Preferred Names

Protein Names

dynein axonemal light chain 4

dynein light chain, outer arm 4

Related Diseases

Diseases

Alias

Mirror Movements 3

MRMV3

Mirror Movements, Type 3

Mirror Movements 1

Congenital Mirror Movement Disorder	Bimanual Synergia
Congenital Mirror Movements	Familial Congenital Controlateral Synkinesia
Familial Congenital Mirror Movements	Hereditary Congenital Controlateral Synkinesia
Hereditary Congenital Mirror Movements	Isolated Congenital Controlateral Synkinesia
Isolated Congenital Mirror Movements	Mirror Movements
MRMV1	Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum
Mirror Movements, Congenital	Bimanual Synkinesis
Cmm	Mirror Movements, Type 1

Expressive Language Disorder

Developmental Expressive Language Disorder

Necrotizing Ulcerative Gingivitis

Acute Necrotizing Ulcerative Gingivitis	Anug
Vincent Angina	Vincent'S Disease
Acute Necrotising Ulcerative Gingivitis	Acute Necrotising Ulcerative Gingivostomatitis
Acute Necrotizing Ulcerative Gingivostomatitis	Acute Ulceromembranous Gingivitis
Angina - Vincents	Early Acute Necrotising Gingivitis
Trench Mouth	Vincent'S Angina
Vincent'S Angina - Pharyngitis	Vincent'S Infection, Any Site
Acute Membranous Gingivitis	Fusospirillary Gingivitis
Fusospirillosis	Phagedenic Gingivitis
Vincent'S Gingivitis	Vincent'S Infection
Vincent'S Stomatitis	Gingivitis, Necrotizing Ulcerative

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Klippel-Feil Syndrome

Cervical Vertebral Fusion	Congenital Dystrophia Brevicollis
Cervical Fusion Syndrome	Klippel-Feil Deformity
Autosomal Dominant Klippel-Feil Syndrome	Congenital Synostosis Of Cervical Vertebrae
Klippel-Feil And Turner Syndrome	Klippel-Feil Deformity, Deafness And Facial Asymmetry
Klippel Feil Syndrome	Cervical Vertebral Fusion Syndrome
Dystrophia Brevicollis Congenita	Fusion Of Cervical Vertebrae
Kfs	Klippel-Feil Sequence
Vertebral Cervical Fusion Syndrome	Klippel-Feil Syndrome, Autosomal Dominant
Klippel-Feil Malformation	Isolated Klippel-Feil Syndrome

Dandy-Walker Syndrome

Dandy-Walker Malformation	DWS
Atresia Of Foramina Of Magendie And Luschka	Dandy-Walker Complex
Dandy-Walker Cyst	Dandy-Walker Deformity
Dandy Walker Cyst	Dw Complex
Dandy-Walker Syndrome Or Malformation	Dandy-Walker Variant
Mega Cisterna Magna	Dwm
Hydrocephalus, Internal, Dandy-Walker Type	Hydrocephalus, Noncommunicating, Dandy-Walker Type
Luschka-Magendie Foramina Atresia	Isolated Dandy-Walker Malformation
Mega-Cisterna Magna	Dandy Walker Variant
Atresia Of Foramen Of Luschka	Atresia Of Foramen Of Magendie
Congenital Blockage Of Foramen Magendie

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03892	DNAL4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAL4	VGNC	VGNC:71945
Rattus norvegicus	DNAL4	RGD	RGD:1309099
Bos taurus	DNAL4	VGNC	VGNC:56196
Mus musculus	DNAL4	MGD	MGI:1859217
Felis catus	DNAL4	VGNC	VGNC:82472
Canis familiaris	DNAL4	VGNC	VGNC:40022

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