DHRS2 - dehydrogenase/reductase 2 Gene

Homo sapiens

Also known as HEP27; SDR25C1

Gene ID: 10202 | Gene type: protein coding

About DHRS2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,630,115-23,645,639 (from NCBI)

This gene has 10 transcripts (splice variants), 692 orthologues and 13 paralogues. Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid Hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

DHRS2 Products(3)

mRNA	Protein	Name
NM_001318835.1	NP_001305764.1	dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3
NM_005794.4	NP_005785.1	dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2
NM_182908.5	NP_878912.1	dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1

DHRS2 Protein Structure

adh_short_C2

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

dehydrogenase/reductase SDR family member 2, mitochondrial

dehydrogenase/reductase (SDR family) member 2

Related Diseases

Diseases

Alias

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Middle Ear Disease

Middle Ear Anomaly

Disorder Of Middle Ear

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Mastoiditis

Mastoiditis Nec

Otorrhea

Discharging Ear

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Ulcerative Blepharitis

Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease	Salpingitis/Oophoritis
Suppurative Salpingo Oophoritis	Tubo-Ovarian Inflammation
Tubo-Ovarian Inflammatory Disorder	Purulent Salpingo Oophoritis
Septic Salpingo Oophoritis	Salpingo-Ovaritis
Inflammation Oviduct	Ruptured Salpingo Oophoritis
Pyosalpinx Rupture

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124711	TBOPP	Inhibitor	99.96%	Unkown
HY-110100	CPYPP	Inhibitor	99.94%	Unkown
HY-153128	DOCK2-IN-1	Inhibitor	96.20%	Unkown
HY-RS03740	DHRS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DHRS2	VGNC	VGNC:84332
Canis familiaris	DHRS2	VGNC	VGNC:39933
Felis catus	DHRS2	VGNC	VGNC:80988
Rattus norvegicus	DHRS2	RGD	RGD:1583909
Mus musculus	DHRS2	MGD	MGI:1918662

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