CTDSPL - CTD small phosphatase like Gene

Homo sapiens

Also known as PSR1; SCP3; HYA22; RBSP3; C3orf8

Gene ID: 10217 | Gene type: protein coding

About CTDSPL

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,861,880-37,984,469 (from NCBI)

This gene has 8 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 20.1), gall bladder (RPKM 14.9) and 25 other tissues.

Summary

Predicted to enable RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

CTDSPL Products(2)

mRNA	Protein	Name
NM_001008392.2	NP_001008393.1	CTD small phosphatase-like protein isoform 1
NM_005808.3	NP_005799.2	CTD small phosphatase-like protein isoform 2

CTDSPL Protein Structure

NIF

0
100
200
276 a.a.

Protein Preferred Names

Protein Names

CTD small phosphatase-like protein

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

Related Diseases

Diseases

Alias

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03293	CTDSPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03294	CTDSPL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTDSPL	VGNC	VGNC:71425
Rattus norvegicus	CTDSPL	RGD	RGD:1304841
Bos taurus	CTDSPL	VGNC	VGNC:106702
Felis catus	CTDSPL	VGNC	VGNC:61249
Mus musculus	CTDSPL	MGD	MGI:1916524

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