CNKSR1 - connector enhancer of kinase suppressor of Ras 1 Gene

Homo sapiens

Also known as CNK; CNK1

Gene ID: 10256 | Gene type: protein coding

About CNKSR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,177,491-26,189,884 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues.

Summary

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CNKSR1 Products(3)

mRNA	Protein	Name
NM_001297647.2	NP_001284576.1	connector enhancer of kinase suppressor of ras 1 isoform 2
NM_001297648.2	NP_001284577.1	connector enhancer of kinase suppressor of ras 1 isoform 3
NM_006314.3	NP_006305.2	connector enhancer of kinase suppressor of ras 1 isoform 1

CNKSR1 Protein Structure

SAM_1

CRIC_ras_sig

0
200
400
600
720 a.a.

Protein Preferred Names

Protein Names

connector enhancer of kinase suppressor of ras 1

CNK homolog protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02888	CNKSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CNKSR1	VGNC	VGNC:97254
Rattus norvegicus	CNKSR1	RGD	RGD:1311879
Mus musculus	CNKSR1	MGD	MGI:2670958
Canis familiaris	CNKSR1	VGNC	VGNC:39403
Macaca mulatta	CNKSR1	VGNC	VGNC:71222
Felis catus	CNKSR1	VGNC	VGNC:61017

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