2. Gene
  3. DNAJA2 - DnaJ heat shock protein family (Hsp40) member A2 Gene

DNAJA2 - DnaJ heat shock protein family (Hsp40) member A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DJ3; CPR3; DJA2; DNAJ; DNJ3; RDJ2; HIRIP4; PRO3015

Gene ID: 10294 | Gene type: protein coding

About DNAJA2

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,955,362-46,973,674 (from NCBI)

This gene has 4 transcripts (splice variants), 300 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 26.8), heart (RPKM 23.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]

DNAJA2 Products(1)

mRNA Protein Name
NM_005880.4 NP_005871.1 dnaJ homolog subfamily A member 2

DNAJA2 Protein Structure

DnaJ

DnaJ: DnaJ domain (9 - 67)

DnaJ_CXXCXGXG

DnaJ_CXXCXGXG: DnaJ central domain (143 - 209)

DnaJ_C

DnaJ_C: DnaJ C terminal domain (266 - 340)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily A member 2

DnaJ (Hsp40) homolog, subfamily A, member 2

Related Diseases

Diseases Alias
Autoimmune Vasculitis
Subacute Bacterial Endocarditis

Endocarditis Lenta

Sbe - Subacute Bacterial Endocarditis

Subacute Endocarditis, Lenta

Endocarditis, Subacute Bacterial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03858 DNAJA2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DNAJA2 MGD MGI:1931882
Rattus norvegicus DNAJA2 RGD RGD:71001
Macaca mulatta DNAJA2 VGNC VGNC:104694