2. Gene
  3. BTN2A2 - butyrophilin subfamily 2 member A2 Gene

BTN2A2 - butyrophilin subfamily 2 member A2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BTF2; BT2.2; BTN2.2

Gene ID: 10385 | Gene type: protein coding

About BTN2A2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,383,108-26,394,874 (from NCBI)

This gene has 16 transcripts (splice variants), 110 orthologues and 15 paralogues. Broad expression in lymph node (RPKM 8.9), appendix (RPKM 6.5) and 24 other tissues.

Summary

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

BTN2A2 Products(6)

mRNA Protein Name
NM_001197237.2 NP_001184166.1 butyrophilin subfamily 2 member A2 isoform a precursor
NM_001197238.2 NP_001184167.1 butyrophilin subfamily 2 member A2 isoform c precursor
NM_001197239.2 NP_001184168.1 butyrophilin subfamily 2 member A2 isoform d precursor
NM_001197240.2 NP_001184169.1 butyrophilin subfamily 2 member A2 isoform e precursor
NM_006995.5 NP_008926.2 butyrophilin subfamily 2 member A2 isoform a precursor
NM_181531.3 NP_853509.1 butyrophilin subfamily 2 member A2 isoform b precursor

BTN2A2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (35 - 133)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (160 - 233)

PRY

PRY: SPRY-associated domain (329 - 377)

SPRY

SPRY: SPRY domain (379 - 488)

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  • 523 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 2 member A2

butyrophilin 2

Recombinant BTN2A2 Proteins

Cat. No. Product Name Accession Purity
HY-P7682 BTN2A2 Protein, Human (HEK293, Fc) Q8WVV5 (Q33-V237) ≥95%
HY-P72344 BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q8WVV5 (Q33-V237) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01672 BTN2A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BTN2A2 MGD MGI:3606486
Rattus norvegicus BTN2A2 RGD RGD:1306973
Others BTN2A2 NCBI