SYCP2 - synaptonemal complex protein 2 Gene

Homo sapiens

Also known as SCP2; SCP-2; SPGF1

Gene ID: 10388 | Gene type: protein coding

About SYCP2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:59,863,571-59,933,637 (from NCBI)

This gene has 9 transcripts (splice variants), 84 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in testis (RPKM 17.7), stomach (RPKM 1.7) and 4 other tissues.

Summary

The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]

SYCP2 Products(1)

mRNA	Protein	Name
NM_014258.4	NP_055073.2	synaptonemal complex protein 2

Protein Preferred Names

Protein Names

synaptonemal complex protein 2

synaptonemal complex lateral element protein

Related Diseases

Diseases

Alias

Spermatogenic Failure 1

Oligosynaptic Infertility	SPGF1
Oligochiasmatic Infertility	Oligochiasmic Infertility

Eccrine Papillary Adenocarcinoma

Digital Papillary Adenocarcinoma	Sweat Gland Adenocarcinoma
Digital Papillary Eccrine Carcinoma Of Skin

Eccrine Adenocarcinoma

Tonsil Squamous Cell Carcinoma

Tonsillar Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Palatine Tonsil

Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14071	SYCP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYCP2	MGD	MGI:1933281
Rattus norvegicus	SYCP2	RGD	RGD:69429
Macaca mulatta	SYCP2	VGNC	VGNC:98454
Felis catus	SYCP2	VGNC	VGNC:65874
Canis familiaris	SYCP2	VGNC	VGNC:47019
Bos taurus	SYCP2	VGNC	VGNC:35509

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