PGRMC2 - progesterone receptor membrane component 2 Gene

Homo sapiens

Also known as DG6; PMBP

Gene ID: 10424 | Gene type: protein coding

About PGRMC2

Cytogenetic location: 4q28.2 Genomic coordinates (GRCh38): 4:128,269,242-128,287,813 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues.

Summary

Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PGRMC2 Products(1)

mRNA	Protein	Name
NM_006320.6	NP_006311.3	membrane-associated progesterone receptor component 2

PGRMC2 Protein Structure

Cyt-b5

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

membrane-associated progesterone receptor component 2

progesterone membrane binding protein

Related Diseases

Diseases

Alias

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Clivus Chordoma

Chordoma Of Clivus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10400	PGRMC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PGRMC2	RGD	RGD:1308804
Bos taurus	PGRMC2	VGNC	VGNC:32802
Canis familiaris	PGRMC2	VGNC	VGNC:44471
Mus musculus	PGRMC2	MGD	MGI:1918054
Felis catus	PGRMC2	VGNC	VGNC:64126
Macaca mulatta	PGRMC2	VGNC	VGNC:107190

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