2. Gene
  3. PFDN6 - prefoldin subunit 6 Gene

PFDN6 - prefoldin subunit 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HKE2; KE-2; PFD6; H2-KE2

Gene ID: 10471 | Gene type: protein coding

About PFDN6

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,289,197-33,290,934 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 198 orthologues. Ubiquitous expression in testis (RPKM 26.0), kidney (RPKM 25.3) and 25 other tissues.

Summary

PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]

PFDN6 Products(4)

mRNA Protein Name
NM_001185181.3 NP_001172110.1 prefoldin subunit 6
NM_001265595.2 NP_001252524.1 prefoldin subunit 6
NM_001265596.1 NP_001252525.1 prefoldin subunit 6
NM_014260.4 NP_055075.1 prefoldin subunit 6

PFDN6 Protein Structure

Prefoldin_2

Prefoldin_2: Prefoldin subunit (10 - 114)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

prefoldin subunit 6

HLA class II region expressed gene KE2

Related Diseases

Diseases Alias
Corneal Dystrophy
Corneal Deposit

Deposits - Cornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10360 PFDN6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PFDN6 RGD RGD:1303006
Bos taurus PFDN6 VGNC VGNC:32768
Macaca mulatta PFDN6 VGNC VGNC:75906
Canis familiaris PFDN6 VGNC VGNC:44441
Mus musculus PFDN6 MGD MGI:95908