ARPC1A - actin related protein 2/3 complex subunit 1A Gene

Homo sapiens

Also known as Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307

Gene ID: 10552 | Gene type: protein coding

About ARPC1A

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,325,898-99,366,262 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 48.9), stomach (RPKM 46.5) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

ARPC1A Products(2)

mRNA	Protein	Name
NM_001190996.2	NP_001177925.1	actin-related protein 2月3日 complex subunit 1A isoform 2
NM_006409.4	NP_006400.2	actin-related protein 2月3日 complex subunit 1A isoform 1

ARPC1A Protein Structure

WD40

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

actin-related protein 2/3 complex subunit 1A

SOP2-like protein

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group G

Fanconi Anemia Complementation Group G

FANCG

Scapuloperoneal Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01013	ARPC1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARPC1A	VGNC	VGNC:50215
Mus musculus	ARPC1A	MGD	MGI:1928896
Canis familiaris	ARPC1A	VGNC	VGNC:49924
Rattus norvegicus	ARPC1A	RGD	RGD:620834
Felis catus	ARPC1A	VGNC	VGNC:80551

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