2. Gene
  3. PAIP1 - poly(A) binding protein interacting protein 1 Gene

PAIP1 - poly(A) binding protein interacting protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 10605 | Gene type: protein coding

About PAIP1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,526,267-43,557,411 (from NCBI)

This gene has 10 transcripts (splice variants), 225 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues.

Summary

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

PAIP1 Products(3)

mRNA Protein Name
NM_006451.5 NP_006442.2 polyadenylate-binding protein-interacting protein 1 isoform 1
NM_182789.4 NP_877590.1 polyadenylate-binding protein-interacting protein 1 isoform 2
NM_183323.3 NP_899152.1 polyadenylate-binding protein-interacting protein 1 isoform 3

PAIP1 Protein Structure

PAM2

PAM2: Ataxin-2 C-terminal region (124 - 140)

MIF4G

MIF4G: MIF4G domain (160 - 376)

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  • 479 a.a.
Protein Preferred Names Protein Names

polyadenylate-binding protein-interacting protein 1

PABC1-interacting protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09981 PAIP1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAIP1 MGD MGI:2384993
Macaca mulatta PAIP1 VGNC VGNC:84476
Rattus norvegicus PAIP1 RGD RGD:1305668