2. Gene
  3. CENPE - centromere protein E Gene

CENPE - centromere protein E Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KIF10; CENP-E; MCPH13; PPP1R61

Gene ID: 1062 | Gene type: protein coding

About CENPE

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:103,105,811-103,198,343 (from NCBI)

This gene has 6 transcripts (splice variants), 147 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 3.4), lymph node (RPKM 3.3) and 18 other tissues.

Summary

Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

CENPE Products(17)

mRNA Protein Name
XM_047449534.1 XP_047305490.1 centromere-associated protein E isoform X5
XM_011531549.3 XP_011529851.1 centromere-associated protein E isoform X10
XM_011531544.3 XP_011529846.1 centromere-associated protein E isoform X1
XM_047449541.1 XP_047305497.1 centromere-associated protein E isoform X15
XM_017007659.2 XP_016863148.1 centromere-associated protein E isoform X12
XM_047449538.1 XP_047305494.1 centromere-associated protein E isoform X11
NM_001286734.2 NP_001273663.1 centromere-associated protein E isoform 2
XM_011531547.3 XP_011529849.1 centromere-associated protein E isoform X6
XM_047449540.1 XP_047305496.1 centromere-associated protein E isoform X14
XM_011531545.3 XP_011529847.1 centromere-associated protein E isoform X2
XM_047449539.1 XP_047305495.1 centromere-associated protein E isoform X13
XM_011531548.3 XP_011529850.1 centromere-associated protein E isoform X7
XM_011531546.4 XP_011529848.1 centromere-associated protein E isoform X3
XM_047449535.1 XP_047305491.1 centromere-associated protein E isoform X8
XM_047449536.1 XP_047305492.1 centromere-associated protein E isoform X9
NM_001813.3 NP_001804.2 centromere-associated protein E isoform 1 precursor
XM_047449533.1 XP_047305489.1 centromere-associated protein E isoform X4

CENPE Protein Structure

Kinesin

Kinesin: Kinesin motor domain (12 - 327)

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  • 2701 a.a.
Protein Preferred Names Protein Names

centromere-associated protein E

Centromere autoantigen E (312kD)

centromere protein E, 312kDa

kinesin family member 10

kinesin-7

kinesin-related protein CENPE

protein phosphatase 1, regulatory subunit 61

Related Diseases

Diseases Alias
Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome

MVA1

Mosaic Variegated Aneuploidy Syndrome, Type 1

Mosaic Variegated Aneuploidy Syndrome

Congenital Chromosomal Disease
Microcephaly 13, Primary, Autosomal Recessive

MCPH13

Primary Autosomal Recessive Microcephaly 13

Microcephaly, Type 13, Primary, Autosomal Recessive
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Microcephaly 5, Primary, Autosomal Recessive

MCPH5

Primary Autosomal Recessive Microcephaly 5

Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern

Microcephaly, Primary Autosomal Recessive, 5
Primary Microcephaly

True Microcephaly

Microcephaly, Primary
Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10299 GSK-923295 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19530 PF-2771 Inhibitor 99.76% Unkown
HY-RS02476 CENPE Human Pre-designed siRNA Set A / Unkown
HY-RS02477 Cenpe Mouse Pre-designed siRNA Set A / Unkown
HY-RS02478 Cenpe Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CENPE VGNC VGNC:27175
Mus musculus CENPE MGD MGI:1098230
Macaca mulatta CENPE VGNC VGNC:71008
Felis catus CENPE VGNC VGNC:60754
Canis familiaris CENPE VGNC VGNC:39103
Rattus norvegicus CENPE RGD RGD:1307115