2. Gene
  3. GAS2L1 - growth arrest specific 2 like 1 Gene

GAS2L1 - growth arrest specific 2 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GAR22

Gene ID: 10634 | Gene type: protein coding

About GAS2L1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,306,650-29,312,787 (from NCBI)

This gene has 10 transcripts (splice variants), 194 orthologues and 7 paralogues. Broad expression in testis (RPKM 11.4), fat (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the Cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]

GAS2L1 Products(6)

mRNA Protein Name
NM_001278730.2 NP_001265659.1 GAS2-like protein 1 isoform c
NM_001362985.3 NP_001349914.1 GAS2-like protein 1 isoform a
NM_001395196.1 NP_001382125.1 GAS2-like protein 1 isoform a
NM_001395197.1 NP_001382126.1 GAS2-like protein 1 isoform a
NM_006478.5 NP_006469.2 GAS2-like protein 1 isoform a
NM_152236.3 NP_689422.1 GAS2-like protein 1 isoform a

GAS2L1 Protein Structure

CH

CH: Calponin homology (CH) domain (31 - 146)

GAS2

GAS2: Growth-Arrest-Specific Protein 2 Domain (206 - 277)

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  • 537 a.a.
Protein Preferred Names Protein Names

GAS2-like protein 1

GAS2-related protein on chromosome 22

Related Diseases

Diseases Alias
Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve

Oculomotor Nerve Disorder

Oculomotor Nerve Paralysis

Third Cranial Nerve Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05283 GAS2L1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GAS2L1 VGNC VGNC:29258
Mus musculus GAS2L1 MGD MGI:1926176
Rattus norvegicus GAS2L1 RGD RGD:1311206
Canis familiaris GAS2L1 VGNC VGNC:41116
Macaca mulatta GAS2L1 VGNC VGNC:72730
Felis catus GAS2L1 VGNC VGNC:107706