ADCY1 - adenylate cyclase 1 Gene

Homo sapiens

Also known as AC1; DFNB44

Gene ID: 107 | Gene type: protein coding

About ADCY1

Cytogenetic location: 7p12.3 Genomic coordinates (GRCh38): 7:45,574,140-45,723,116 (from NCBI)

This gene has 5 transcripts (splice variants), 294 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 14.3), testis (RPKM 1.6) and 7 other tissues.

Summary

This gene encodes a member of the of Adenylate Cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/Calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ADCY1 Products(2)

mRNA	Protein	Name
NM_001281768.2	NP_001268697.1	adenylate cyclase type 1 isoform 2
NM_021116.4	NP_066939.1	adenylate cyclase type 1 isoform 1

ADCY1 Protein Structure

Guanylate_cyc

0
200
400
600
800
1000
1119 a.a.

Protein Preferred Names

Protein Names

adenylate cyclase type 1

3',5'-cyclic AMP synthetase

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 44

DFNB44	Autosomal Recessive Nonsyndromic Deafness 44
Autosomal Recessive Deafness 44	Deafness, Autosomal Recessive, 44
Deafness, Autosomal Recessive, Type 44

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Intracranial Vasospasm

Vasospasm, Intracranial

Portal Hypertension

Hypertension, Portal	Hypertension Portal
Pht - [Portal Hypertension]	Portal Htn

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00326	ADCY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADCY1	RGD	RGD:1309318
Canis familiaris	ADCY1	VGNC	VGNC:37618
Mus musculus	ADCY1	MGD	MGI:99677
Felis catus	ADCY1	VGNC	VGNC:59613
Macaca mulatta	ADCY1	VGNC	VGNC:69505
Bos taurus	ADCY1	VGNC	VGNC:25642

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