ADAM28 - ADAM metallopeptidase domain 28 Gene

Homo sapiens

Also known as MDCL; MDC-L; eMDCII; ADAM 28; eMDC II

Gene ID: 10863 | Gene type: protein coding

About ADAM28

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:24,294,069-24,359,014 (from NCBI)

This gene has 13 transcripts (splice variants), 247 orthologues and 20 paralogues. Biased expression in stomach (RPKM 21.4), gall bladder (RPKM 11.1) and 12 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ADAM28 Products(3)

mRNA	Protein	Name
NM_001304351.2	NP_001291280.1	disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein
NM_014265.6	NP_055080.2	disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein
NM_021777.5	NP_068547.2	disintegrin and metalloproteinase domain-containing protein 28 isoform 3 preproprotein

ADAM28 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
775 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 28

epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

Related Diseases

Diseases

Alias

Hyperostosis Cranialis Interna

HCIN	Hyperostosis Cranalis Interna

Epilepsy, Familial Temporal Lobe, 1

ETL1	Adpeaf
Adlte	Epilepsy, Partial, With Auditory Features
Autosomal Dominant Partial Epilepsy With Auditory Features	Epilepsy, Lateral Temporal Lobe, Autosomal Dominant
Familial Temporal Lobe Epilepsy 1	Partial Epilepsy With Auditory Features
Autosomal Dominant Lateral Temporal Lobe Epilepsy	Lateral Temporal Lobe Epilepsy Autosomal Dominant
Epilepsy, Temporal Lobe, Familial, Type 1

Hyperostosis

Hypertrophy Of Bone	Bone Hypertrophy
Bone Thickening	Periosteum Thickening

Asbestos-Related Lung Carcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00280	ADAM28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADAM28	VGNC	VGNC:69486
Canis familiaris	ADAM28	VGNC	VGNC:37582
Felis catus	ADAM28	VGNC	VGNC:59582
Rattus norvegicus	ADAM28	RGD	RGD:727820
Mus musculus	ADAM28	MGD	MGI:105988
Others	ADAM28	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.