2. Gene
  3. LILRB4 - leukocyte immunoglobulin like receptor B4 Gene

LILRB4 - leukocyte immunoglobulin like receptor B4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as B4; ILT3; LIR5; CD85K; ILT-3; LIR-5

Gene ID: 11006 | Gene type: protein coding

About LILRB4

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,662,985-54,668,718 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 296 orthologues and 25 paralogues. Broad expression in appendix (RPKM 9.2), lymph node (RPKM 8.1) and 17 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB4 Products(12)

mRNA Protein Name
NM_001278426.4 NP_001265355.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1 precursor
NM_001278427.4 NP_001265356.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor
NM_001278428.4 NP_001265357.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 3 precursor
NM_001278429.4 NP_001265358.3 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 4
NM_001278430.4 NP_001265359.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 5 precursor
NM_001394933.1 NP_001381862.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 6 precursor
NM_001394934.1 NP_001381863.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 7 precursor
NM_001394935.1 NP_001381864.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 8 precursor
NM_001394936.1 NP_001381865.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 9
NM_001394937.1 NP_001381866.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 10
NM_001394938.1 NP_001381867.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 11
NM_001394939.1 NP_001381868.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 12 precursor

LILRB4 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 115)

Ig_3

Ig_3: Immunoglobulin domain (123 - 198)

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  • 449 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 4

CD85 antigen-like family member K

Recombinant LILRB4 Proteins

Cat. No. Product Name Accession Purity
HY-P72519 LILRB4/CD85k/ILT3 Protein, Human (HEK293, His) Q8NHJ6 (Q22-E259) ≥95%
HY-P76439 LILRB4/CD85k/ILT3 Protein, Human (259a.a, HEK293, His) Q8NHJ6 (M1-E259) ≥95%
HY-P76440 LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, HEK293, His) Q8NHJ6 (M1-E259) ≥95%
HY-P76441 LILRB4/CD85k/ILT3 Protein, Human (237a.a, HEK293, Fc) NP_001265356.2 (M21-H257) ≥95%
HY-P77741 LILRB4/CD85k/ILT3 Protein, Human (Domain1&2, HEK293, His) Q8NHJ6 (P27-S218) ≥95%
HY-P77742 LILRB4/CD85k/ILT3 Protein, Human (HEK293, Fc) Q8NHJ6 (Q22-R256) ≥95%
HY-P77743 LILRB4/CD85k/ILT3 Protein, Human (HEK293, His-Avi) Q8NHJ6 (Q22-H257) ≥95%
HY-P77744 LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, HEK293, His-Avi) Q8NHJ6 (Q22-H257) ≥95%
HY-P78645 FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, His) Q8NHJ6 (Q22-H257) ≥95%
HY-P78646 FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, Fc) Q8NHJ6 (Q22-R256) ≥95%
HY-P700779 LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, Domain 1, HEK293, His-Avi) AAH26309.1 (Q22-T118) ≥95%
HY-P700780 LILRB4/CD85k/ILT3 Protein, Human (Domain 1, HEK293, His-Avi) AAH26309.1 (Q22-T118) ≥95%
HY-P701018 LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, 141a.a, HEK293, His-Avi) AAH26309.1 (G119-E259) ≥95%
HY-P701064 LILRB4/CD85k/ILT3 Domain 1+hinge Protein, Human (Biotinylated, HEK293, His-Avi) AAH26309.1 (Q22-K123) ≥95%
HY-P701065 LILRB4/CD85k/ILT3 Domain 1+hinge Protein, Human (HEK293, His-Avi) AAH26309.1 (Q22-K123) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07654 LILRB4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LILRB4 RGD RGD:1359090
Macaca fascicularis LILRB4 NCBI
Mus musculus LILRB4 NCBI
Others LILRB4 NCBI