2. Gene
  3. Acat1 - acetyl-Coenzyme A acetyltransferase 1 Gene

Acat1 - acetyl-Coenzyme A acetyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Acat; 6330585C21Rik

Gene ID: 110446 | Gene type: protein coding

About Acat1

Chromosome 9: 53,491,822-53,521,682 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 202 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in liver E18 (RPKM 193.6), heart adult (RPKM 69.) and 2 other tissues.

Summary

Enables acetyl-CoA C-acetyltransferase activity. Predicted to be involved in carboxylic acid catabolic process; ketone body catabolic process; and purine nucleoside bisphosphate metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in brain; embryo; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Acat1 Products(1)

mRNA Protein Name
NM_144784.3 NP_659033.1 acetyl-CoA acetyltransferase, mitochondrial precursor

Acat1 Protein Structure

thiolase

thiolase: cd00751 (39 - 422)

  • 0
  • 100
  • 200
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  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

acetyl-CoA acetyltransferase, mitochondrial

acetoacetyl-CoA thiolase

Related Agents

Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-13215 Avasimibe Inhibitor 99.50% Phase 3
HY-100401A Pactimibe sulfate Inhibitor 98.22% Phase 3
HY-100401 Pactimibe Inhibitor 98.07% Phase 3
HY-100400A K-604 dihydrochloride Inhibitor ≥99.0% Phase 2
HY-100399A Nevanimibe hydrochloride Inhibitor 99.92% Phase 2
HY-100399 Nevanimibe Inhibitor / Phase 2

Orthologs Information

Species Symbol Source ID
Homo sapiens Acat1 NCBI NCBI:38