CPSF6 - cleavage and polyadenylation specific factor 6 Gene

Homo sapiens

Also known as CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7

Gene ID: 11052 | Gene type: protein coding

About CPSF6

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,239,569-69,274,358 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 15.0) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

CPSF6 Products(2)

mRNA	Protein	Name
NM_001300947.2	NP_001287876.1	cleavage and polyadenylation specificity factor subunit 6 isoform 2
NM_007007.3	NP_008938.2	cleavage and polyadenylation specificity factor subunit 6 isoform 1

CPSF6 Protein Structure

0
100
200
300
400
500
551 a.a.

Protein Preferred Names

Protein Names

cleavage and polyadenylation specificity factor subunit 6

CPSF 68 kDa subunit

Related Diseases

Diseases

Alias

Carnitine-Acylcarnitine Translocase Deficiency

Cact Deficiency	Carnitine Acylcarnitine Translocase Deficiency
CACTD	Carnitine-Acylcarnitine Carrier Deficiency

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120072	PF-3450074	Inhibitor	98.44%	Unkown
HY-RS03120	CPSF6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CPSF6	VGNC	VGNC:61144
Mus musculus	CPSF6	MGD	MGI:1913948
Macaca mulatta	CPSF6	VGNC	VGNC:71401
Bos taurus	CPSF6	VGNC	VGNC:27674
Canis familiaris	CPSF6	VGNC	VGNC:39577
Rattus norvegicus	CPSF6	RGD	RGD:1304640

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