Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Mus musculus

Also known as MR; Mlr

Gene ID: 110784 | Gene type: protein coding

About Nr3c2

Chromosome 8: 77,626,070-77,971,641 forward strand.GRCm39:CM001001.3

This gene has 8 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 23 phenotypes. Broad expression in colon adult (RPKM 12.), frontal lobe adult (RPKM 3.4) and 2 other tissues.

Summary

Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 Products(1)

mRNA	Protein	Name
NM_001083906.2	NP_001077375.1	mineralocorticoid receptor

Nr3c2 Protein Structure

Herpes_BLLF1

NR_DBD_GR_PR

NR_LBD_MR

0
200
400
600
800
980 a.a.

Protein Preferred Names

Protein Names

mineralocorticoid receptor

aldosterone receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09547	NR3C2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09548	Nr3c2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09549	Nr3c2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr3c2	NCBI	NCBI:4306

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