2. Gene
  3. DNAJB4 - DnaJ heat shock protein family (Hsp40) member B4 Gene

DNAJB4 - DnaJ heat shock protein family (Hsp40) member B4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DjB4; HLJ1; DNAJW

Gene ID: 11080 | Gene type: protein coding

About DNAJB4

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,979,175-78,017,964 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 27.3), thyroid (RPKM 23.6) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

DNAJB4 Products(6)

mRNA Protein Name
NM_001317099.2 NP_001304028.1 dnaJ homolog subfamily B member 4 isoform a
NM_001317100.2 NP_001304029.1 dnaJ homolog subfamily B member 4 isoform b
NM_001317101.2 NP_001304030.1 dnaJ homolog subfamily B member 4 isoform c
NM_001317102.2 NP_001304031.1 dnaJ homolog subfamily B member 4 isoform c
NM_001317103.2 NP_001304032.1 dnaJ homolog subfamily B member 4 isoform d
NM_007034.5 NP_008965.2 dnaJ homolog subfamily B member 4 isoform a

DNAJB4 Protein Structure

DnaJ

DnaJ: DnaJ domain (4 - 65)

DnaJ_C

DnaJ_C: DnaJ C terminal domain (249 - 328)

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  • 337 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily B member 4

DnaJ (Hsp40) homolog, subfamily B, member 4

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03867 DNAJB4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DNAJB4 VGNC VGNC:80183
Bos taurus DNAJB4 VGNC VGNC:55166
Rattus norvegicus DNAJB4 RGD RGD:1305826
Macaca mulatta DNAJB4 VGNC VGNC:106351
Mus musculus DNAJB4 MGD MGI:1914285
Canis familiaris DNAJB4 VGNC VGNC:49082