2. Gene
  3. INMT - indolethylamine N-methyltransferase Gene

INMT - indolethylamine N-methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TEMT

Gene ID: 11185 | Gene type: protein coding

About INMT

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,752,135-30,757,602 (from NCBI)

This gene has 4 transcripts (splice variants), 80 orthologues and 2 paralogues. Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues.

Summary

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an Enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]

INMT Products(2)

mRNA Protein Name
NM_001199219.2 NP_001186148.1 indolethylamine N-methyltransferase isoform 2
NM_006774.5 NP_006765.4 indolethylamine N-methyltransferase isoform 1

INMT Protein Structure

NNMT_PNMT_TEMT

NNMT_PNMT_TEMT: NNMT/PNMT/TEMT family (4 - 259)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

indolethylamine N-methyltransferase

amine N-methyltransferase

Related Diseases

Diseases Alias
Hallucinogen Abuse
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06820 INMT Human Pre-designed siRNA Set A / Unkown
HY-124101 PDAT Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta INMT VGNC VGNC:108416
Rattus norvegicus INMT RGD RGD:1597087
Mus musculus INMT MGD MGI:102963