MRPL3 - mitochondrial ribosomal protein L3 Gene

Homo sapiens

Also known as MRL3; RPML3; COXPD9

Gene ID: 11222 | Gene type: protein coding

About MRPL3

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,462,212-131,502,971 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 34.3), colon (RPKM 33.4) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]

MRPL3 Products(1)

mRNA	Protein	Name
NM_007208.4	NP_009139.1	39S ribosomal protein L3, mitochondrial

MRPL3 Protein Structure

Ribosomal_L3

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

39S ribosomal protein L3, mitochondrial

L3mt

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 9

COXPD9	Combined Oxidative Phosphorylation Defect Type 9
Combined Oxidative Phosphorylation Deficiency, Type 9

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Marshall-Smith Syndrome

MRSHSS	Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome
Mss

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08669	MRPL3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MRPL3	VGNC	VGNC:74725
Mus musculus	MRPL3	MGD	MGI:2137204
Rattus norvegicus	MRPL3	RGD	RGD:1306391
Canis familiaris	MRPL3	VGNC	VGNC:43390
Bos taurus	MRPL3	VGNC	VGNC:31630
Felis catus	MRPL3	VGNC	VGNC:63601

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