CHN2 - chimerin 2 Gene

Homo sapiens

Also known as BCH; CHN2-3; ARHGAP3; RHOGAP3

Gene ID: 1124 | Gene type: protein coding

About CHN2

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:29,146,591-29,514,328 (from NCBI)

This gene has 30 transcripts (splice variants), 223 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 21.4), small intestine (RPKM 16.7) and 20 other tissues.

Summary

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

CHN2 Products(14)

mRNA	Protein	Name
NM_001039936.3	NP_001035025.1	beta-chimaerin isoform 1
NM_001293070.2	NP_001279999.1	beta-chimaerin isoform 4
NM_001293071.2	NP_001280000.1	beta-chimaerin isoform 5
NM_001293072.2	NP_001280001.1	beta-chimaerin isoform 6
NM_001293073.2	NP_001280002.1	beta-chimaerin isoform 7
NM_001293075.2	NP_001280004.1	beta-chimaerin isoform 8
NM_001293076.2	NP_001280005.1	beta-chimaerin isoform 9
NM_001293077.2	NP_001280006.1	beta-chimaerin isoform 10
NM_001293078.2	NP_001280007.1	beta-chimaerin isoform 11
NM_001293079.2	NP_001280008.1	beta-chimaerin isoform 12
NM_001293080.2	NP_001280009.1	beta-chimaerin isoform 13
NM_001293081.2	NP_001280010.1	beta-chimaerin isoform 14
NM_001398427.1	NP_001385356.1	beta-chimaerin isoform 15
NM_004067.4	NP_004058.1	beta-chimaerin isoform 2

CHN2 Protein Structure

SH2

C1_1

RhoGAP

0
100
200
300
400
468 a.a.

Protein Preferred Names

Protein Names

beta-chimaerin

beta-chimerin

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Duodenum Adenocarcinoma

Duodenal Adenocarcinoma

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease	Dejerine-Sottas Syndrome
Charcot-Marie-Tooth Disease Type 3	DSS
Hereditary Motor And Sensory Neuropathy Type Iii	Hmsn3
Dejerine-Sottas Neuropathy	Hmsn Iii
Charcot-Marie-Tooth Disease, Type 3	Cmt3
Dsn	Hmsn 3
Hereditary Motor And Sensory Neuropathy Type 3	Hereditary Motor And Sensory Neuropathy 3
Hypertrophic Neuropathy Of Infancy	Charcot-Marie-Tooth Disease Demyelinating Type 4f
Charcot-Marie-Tooth Disease Type 4f	Charcot-Marie-Tooth Neuropathy Type 4f
Cmt4f	Hereditary Motor And Sensory Neuropathy Iii
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108137	Z-LVG-CHN2	Inhibitor	99.88%	Unkown
HY-108137A	Z-L(D-Val)G-CHN2	Inhibitor	99.35%	Unkown
HY-RS02650	CHN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHN2	VGNC	VGNC:49738
Felis catus	CHN2	VGNC	VGNC:69373
Mus musculus	CHN2	MGD	MGI:1917243
Bos taurus	CHN2	VGNC	VGNC:50060
Rattus norvegicus	CHN2	RGD	RGD:620140
Macaca mulatta	CHN2	VGNC	VGNC:80861

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