2. Gene
  3. SNF8 - SNF8 subunit of ESCRT-II Gene

SNF8 - SNF8 subunit of ESCRT-II Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Dot3; EAP30; VPS22

Gene ID: 11267 | Gene type: protein coding

About SNF8

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,929,316-48,944,842 (from NCBI)

This gene has 17 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in kidney (RPKM 18.5), fat (RPKM 18.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SNF8 Products(4)

mRNA Protein Name
NM_001317192.2 NP_001304121.1 vacuolar-sorting protein SNF8 isoform 2
NM_001317193.2 NP_001304122.1 vacuolar-sorting protein SNF8 isoform 3
NM_001317194.2 NP_001304123.1 vacuolar-sorting protein SNF8 isoform 4
NM_007241.4 NP_009172.2 vacuolar-sorting protein SNF8 isoform 1

SNF8 Protein Structure

EAP30

EAP30: EAP30/Vps36 family (6 - 225)

  • 0
  • 100
  • 200
  • 258 a.a.
Protein Preferred Names Protein Names

vacuolar-sorting protein SNF8

EAP30 subunit of ELL complex

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13490 SNF8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SNF8 RGD RGD:1310144
Felis catus SNF8 VGNC VGNC:99457
Macaca mulatta SNF8 VGNC VGNC:77729
Mus musculus SNF8 MGD MGI:1343161
Canis familiaris SNF8 VGNC VGNC:46601
Bos taurus SNF8 VGNC VGNC:35064