2. Gene
  3. Ada - adenosine deaminase Gene

Ada - adenosine deaminase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 11486 | Gene type: protein coding

About Ada

Chromosome 2: 163,568,504-163,592,159 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 40 phenotypes. Biased expression in small intestine adult (RPKM 276.4), placenta adult (RPKM 134.5) and 4 other tissues.

Summary

Enables 2'-deoxyadenosine deaminase activity; Adenosine Deaminase activity; and zinc ion binding activity. Involved in allantoin metabolic process and purine nucleoside monophosphate metabolic process. Acts upstream of or within several processes, including animal organ development; nucleobase-containing small molecule metabolic process; and positive regulation of lymphocyte activation. Located in cytoplasm. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Used to study Adenosine Deaminase deficiency. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]

Ada Products(2)

mRNA Protein Name
NM_007398.4 NP_031424.1 adenosine deaminase
NM_001272052.1 NP_001258981.1 adenosine deaminase

Ada Protein Structure

A_deaminase

A_deaminase: pfam00962 (9 - 335)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

adenosine deaminase

adenosine aminohydrolase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-17377 Vicriviroc maleate 99.91% Phase 3
HY-105017 Evodenoson Agonist / Phase 2
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103160A EHNA hydrochloride Inhibitor 99.61% Unkown
HY-W011552 2'-O-Methyladenosine 99.44% Unkown
HY-116578 Metopimazine 98.03% Unkown
HY-N7368 Hibifolin Inhibitor 99.70% Unkown
HY-103237 L-Adenosine Inhibitor ≥97.0% Unkown
HY-103159 1-Deazaadenosine Inhibitor ≥98.0% Unkown
HY-D0855 ADA ≥97.0% Unkown
HY-117260 Coformycin Inhibitor / Unkown
HY-158009 SGF29-IN-1 Inhibitor / Unkown
HY-P5201S VTSEGAGLQLQK-13C6,15N2 / Unkown
HY-RS00258 ADA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00259 Ada Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00260 Ada Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00261 ADA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W753672 2'-O-Methyladenosine-d3 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ada NCBI NCBI:100
Macaca fascicularis Ada NCBI NCBI:102137458
Rattus norvegicus Ada NCBI NCBI:24165
Macaca mulatta Ada NCBI NCBI:717897