2. Gene
  3. GBP5 - guanylate binding protein 5 Gene

GBP5 - guanylate binding protein 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GBP-5

Gene ID: 115362 | Gene type: protein coding

About GBP5

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,256,189-89,272,860 (from NCBI)

This gene has 5 transcripts (splice variants), 98 orthologues and 10 paralogues. Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues.

Summary

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

GBP5 Products(3)

mRNA Protein Name
NM_001134486.4 NP_001127958.1 guanylate-binding protein 5 isoform 1
NM_001391920.1 NP_001378849.1 guanylate-binding protein 5 isoform 2
NM_052942.5 NP_443174.1 guanylate-binding protein 5 isoform 1

GBP5 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (18 - 280)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (282 - 573)

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  • 586 a.a.
Protein Preferred Names Protein Names

guanylate-binding protein 5

GBP-TA antigen

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05311 GBP5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GBP5 RGD RGD:1311040
Mus musculus GBP5 MGD MGI:2429943
Bos taurus GBP5 VGNC VGNC:59183