2. Gene
  3. Parp1 - poly (ADP-ribose) polymerase family, member 1 Gene

Parp1 - poly (ADP-ribose) polymerase family, member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PARP; PPOL; ARTD1; Adprp; Adprt1; msPARP; parp-1; sPARP-1; 5830444G22Rik

Gene ID: 11545 | Gene type: protein coding

About Parp1

Chromosome 1: 180,396,489-180,428,819 forward strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 48 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 6.8), CNS E14 (RPKM 38.) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; Bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]

Parp1 Products(1)

mRNA Protein Name
NM_007415.3 NP_031441.2 poly [ADP-ribose] polymerase 1

Parp1 Protein Structure

PLN03123

PLN03123: cl33639 (8 - 1009)

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  • 1014 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase 1

ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1

ADP-ribosyltransferase diphtheria toxin-like 1

ADPRT 1

DNA ADP-ribosyltransferase PARP1

NAD(+) ADP-ribosyltransferase 1

poly(ADP-ribose) polymerase

poly[ADP-ribose] synthase 1

poly[ADP-ribose] synthetase 1

protein poly-ADP-ribosyltransferase PARP1

Recombinant Parp1 Proteins

Cat. No. Product Name Accession Purity
HY-P73337 PARP Protein, Mouse (sf9, His) Q921K2 (M1-W1014) ≥95%

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10162 Olaparib Inhibitor 99.98% Yes
HY-16106 Talazoparib Inhibitor 99.89% Unkown
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.80% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-114778 Fluzoparib Inhibitor 99.85% Unkown
HY-10619A Niraparib hydrochloride Inhibitor 99.76% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-10129 Veliparib Inhibitor 99.92% Phase 3
HY-12015 Iniparib Inhibitor 99.82% Phase 3
HY-10130 Veliparib dihydrochloride Inhibitor 99.96% Phase 3
HY-132167 Saruparib Inhibitor 99.79% Phase 2
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
HY-13326 ASP3026 99.73% Phase 1
HY-115552 Simmiparib Inhibitor 99.51% Phase 1
Pre-clinical Phase
Bioactive Molecules (65)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-13594 Chlorin e6 97.24% Unkown
HY-13688A PJ34 Inhibitor 98.11% Unkown
HY-12032 AG14361 Inhibitor 99.44% Unkown
HY-13688 PJ34 hydrochloride Inhibitor 99.91% Unkown
HY-N3584 Paris saponin VII Inhibitor 99.96% Unkown
HY-139156 SK-575 Inhibitor 99.51% Unkown
HY-N0213 Peiminine 99.94% Unkown
HY-150207 RBN-3143 Inhibitor 99.24% Unkown
HY-137457 Venadaparib Inhibitor 98.11% Unkown
HY-12975 AZ6102 Inhibitor 99.65% Unkown
HY-130644 iRucaparib-AP6 Degrader 99.93% Unkown
HY-100225 ME0328 Inhibitor 99.59% Unkown
HY-14478 UPF 1069 Inhibitor 99.10% Unkown
HY-18954 NMS-P118 Inhibitor 99.78% Unkown
HY-19351 MN-64 Inhibitor 99.73% Unkown
HY-122661 Mefuparib hydrochloride Inhibitor 98.94% Unkown
HY-117889 PARP14 inhibitor H10 Inhibitor 98.04% Unkown
HY-10619D Niraparib (R-enantiomer) Inhibitor 99.69% Unkown
HY-108632 BYK204165 Inhibitor 98.66% Unkown
HY-10614 A-966492 Inhibitor 99.95% Unkown
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.21% Unkown
HY-16106A (8R,9S)-Talazoparib Inhibitor 98.36% Unkown
HY-148566 OUL232 Inhibitor 99.82% Unkown
HY-123851 MSC2504877 Inhibitor 98.50% Unkown
HY-128599 NMS-P515 Inhibitor 98.18% Unkown
HY-156419 PARP7-IN-16 Inhibitor / Unkown
HY-147886 PARP1-IN-11 Inhibitor 98.58% Unkown
HY-114324 PROTAC PARP1 degrader Inhibitor 99.32% Unkown
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.43% Unkown
HY-N1094 Verminoside Activator ≥98.0% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.89% Unkown
HY-105692 DR2313 Inhibitor 98.70% Unkown
HY-147027 PARP-1-IN-2 Inhibitor 98.80% Unkown
HY-132297 PARP1-IN-5 Inhibitor / Unkown
HY-137457A Venadaparib hydrochloride Inhibitor / Unkown
HY-145749 PARPYnD Inhibitor / Unkown
HY-149001 PARP1-IN-9 Inhibitor / Unkown
HY-105253 PARP-2/1-IN-2 Inhibitor / Unkown
HY-147101 SK-575-NEG Inhibitor / Unkown
HY-155766 PARP1-IN-14 Inhibitor / Unkown
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / Unkown
HY-161083 PARP/EZH2-IN-2 Inhibitor / Unkown
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-146548 Anticancer agent 43 Inducer 98.58% Unkown
HY-158045 PROTAC PARP1 degrader-1 Inhibitor / Unkown
HY-15046 EB-47 Inhibitor / Unkown
HY-157137 PARP1-IN-17 / Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor / Unkown
HY-161372 PARP1/c-Met-IN-1 Inhibitor / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-150765 PARP1-IN-12 Inhibitor / Unkown
HY-144338 PARP1/BRD4-IN-1 Inhibitor / Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-150613 PARP1/BRD4-IN-2 Inhibitor / Unkown
HY-155993 YCH1899 Inhibitor / Unkown
HY-162114 PARP1-IN-18 Inhibitor / Unkown
HY-149800 PARP-1-IN-3 Inhibitor 99.30% Unkown
HY-136489A KU-0058948 hydrochloride Inhibitor / Unkown
HY-147030 PARP1-IN-8 Inhibitor 99.29% Unkown
HY-149003 PARP1-IN-10 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-U00223 WD2000-012547 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp1 NCBI NCBI:142