2. Gene
  3. CLNK - cytokine dependent hematopoietic cell linker Gene

CLNK - cytokine dependent hematopoietic cell linker Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MIST

Gene ID: 116449 | Gene type: protein coding

About CLNK

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:10,486,395-10,734,846 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 3 paralogues. Biased expression in kidney (RPKM 1.1), lymph node (RPKM 0.5) and 12 other tissues.

Summary

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

CLNK Products(1)

mRNA Protein Name
NM_052964.4 NP_443196.2 cytokine-dependent hematopoietic cell linker

CLNK Protein Structure

SH2

SH2: SH2 domain (309 - 392)

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  • 428 a.a.
Protein Preferred Names Protein Names

cytokine-dependent hematopoietic cell linker

mast cell immunoreceptor signal transducer

Related Diseases

Diseases Alias
Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02826 CLNK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLNK VGNC VGNC:27454
Macaca mulatta CLNK VGNC VGNC:71196
Rattus norvegicus CLNK RGD RGD:1562417
Felis catus CLNK VGNC VGNC:60969
Mus musculus CLNK MGD MGI:1351468
Canis familiaris CLNK VGNC VGNC:39352